| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 10 | 1 | 2021-09-04 | Syracuse | @ | Ohio | REG (Non-Conf) | W 29-9 |
| 2 | 11 | 2 | 2021-09-11 | Syracuse | Rutgers | REG (Non-Conf) | L 7-17 | |
| 3 | 12 | 3 | 2021-09-18 | Syracuse | Albany | REG (Non-Conf) | W 62-24 | |
| 4 | 13 | 4 | 2021-09-24 | Syracuse | Liberty | REG (Non-Conf) | W 24-21 | |
| 5 | 14 | 5 | 2021-10-02 | Syracuse | @ | Florida State | REG (Conf) | L 30-33 |
| 6 | 15 | 6 | 2021-10-09 | Syracuse | Wake Forest | REG (Conf) | L 37-40 | |
| 7 | 16 | 7 | 2021-10-15 | Syracuse | Clemson | REG (Conf) | L 14-17 | |
| 8 | 17 | 8 | 2021-10-23 | Syracuse | @ | Virginia Tech | REG (Conf) | W 41-36 |
| 9 | 18 | 9 | 2021-10-30 | Syracuse | Boston College | REG (Conf) | W 21-6 | |
| 10 | 19 | 11 | 2021-11-20 | Syracuse | @ | North Carolina State | REG (Conf) | L 17-41 |
| 11 | 20 | 12 | 2021-11-27 | Syracuse | Pitt | REG (Conf) | L 14-31 | |
| 5-6 |
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