| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 15 | 1 | 2021-09-04 | Houston | N | Texas Tech | REG (Non-Conf) | L 21-38 | |
| 2 | 16 | 2 | 2021-09-11 | Houston | @ | Rice | REG (Non-Conf) | W 44-7 | |
| 3 | 17 | 3 | 2021-09-18 | Houston | Grambling | REG (Non-Conf) | W 45-0 | ||
| 4 | 18 | 4 | 2021-09-25 | Houston | Navy | REG (Conf) | W 28-20 | ||
| 5 | 19 | 5 | 2021-10-01 | Houston | @ | Tulsa | REG (Conf) | W 45-10 | |
| 6 | 20 | 6 | 2021-10-07 | Houston | @ | Tulane | REG (Conf) | W 40-22 | |
| 7 | 21 | 7 | 2021-10-23 | Houston | East Carolina | REG (Conf) | W 31-24 | ||
| 8 | 22 | 8 | 2021-10-30 | Houston | SMU | REG (Conf) | W 44-37 | ||
| 9 | 23 | 9 | 2021-11-06 | Houston | @ | South Florida | REG (Conf) | W 54-42 | |
| 10 | 24 | 10 | 2021-11-13 | Houston | @ | Temple | REG (Conf) | W 37-8 | |
| 11 | 25 | 11 | 2021-11-19 | Houston | Memphis | REG (Conf) | W 31-13 | ||
| 12 | 26 | 12 | 2021-11-27 | Houston | @ | Connecticut | REG (Non-Conf) | W 45-17 | |
| 13 | 27 | 13 | 2021-12-04 | Houston | @ | Cincinnati | Conf Championship | L 20-35 | |
| 14 | 28 | 14 | 2021-12-28 | Houston | N | Auburn | Bowl | W 17-13 | Birmingham Bowl |
| 12-2 |
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