| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 16 | 1 | 2022-09-03 | Iowa State | Southeast Mo. St. | REG (Non-Conf) | W 42-10 | |
| 2 | 17 | 2 | 2022-09-10 | Iowa State | @ | Iowa | REG (Non-Conf) | W 10-7 |
| 3 | 18 | 3 | 2022-09-17 | Iowa State | Ohio | REG (Non-Conf) | W 43-10 | |
| 4 | 19 | 4 | 2022-09-24 | Iowa State | Baylor | REG (Conf) | L 24-31 | |
| 5 | 20 | 5 | 2022-10-01 | Iowa State | @ | Kansas | REG (Conf) | L 11-14 |
| 6 | 21 | 6 | 2022-10-08 | Iowa State | Kansas State | REG (Conf) | L 9-10 | |
| 7 | 22 | 7 | 2022-10-15 | Iowa State | @ | Texas | REG (Conf) | L 21-24 |
| 8 | 23 | 8 | 2022-10-29 | Iowa State | Oklahoma | REG (Conf) | L 13-27 | |
| 9 | 24 | 9 | 2022-11-05 | Iowa State | West Virginia | REG (Conf) | W 31-14 | |
| 10 | 25 | 10 | 2022-11-12 | Iowa State | @ | Oklahoma State | REG (Conf) | L 14-20 |
| 11 | 26 | 11 | 2022-11-19 | Iowa State | Texas Tech | REG (Conf) | L 10-14 | |
| 12 | 27 | 12 | 2022-11-26 | Iowa State | @ | Texas Christian | REG (Conf) | L 14-62 |
| 4-8 |
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