| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 11 | 1 | 2021-09-04 | Oklahoma State | Missouri St. | REG (Non-Conf) | W 23-16 | ||
| 2 | 12 | 2 | 2021-09-11 | Oklahoma State | Tulsa | REG (Non-Conf) | W 28-23 | ||
| 3 | 13 | 4 | 2021-09-25 | Oklahoma State | Kansas State | REG (Conf) | W 31-20 | ||
| 4 | 14 | 5 | 2021-10-02 | Oklahoma State | Baylor | REG (Conf) | W 24-14 | ||
| 5 | 15 | 6 | 2021-10-16 | Oklahoma State | @ | Texas | REG (Conf) | W 32-24 | |
| 6 | 16 | 7 | 2021-10-23 | Oklahoma State | @ | Iowa State | REG (Conf) | L 21-24 | |
| 7 | 17 | 8 | 2021-10-30 | Oklahoma State | Kansas | REG (Conf) | W 55-3 | ||
| 8 | 18 | 9 | 2021-11-06 | Oklahoma State | @ | West Virginia | REG (Conf) | W 24-3 | |
| 9 | 19 | 11 | 2021-11-20 | Oklahoma State | @ | Texas Tech | REG (Conf) | W 23-0 | |
| 10 | 20 | 12 | 2021-11-27 | Oklahoma State | Oklahoma | REG (Conf) | W 37-33 | ||
| 11 | 21 | 13 | 2021-12-04 | Oklahoma State | N | Baylor | Conf Championship | L 16-21 | |
| 12 | 22 | 14 | 2022-01-01 | Oklahoma State | N | Notre Dame | Bowl | W 37-35 | Fiesta Bowl |
| 10-2 |
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