| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 9 | 1 | 2021-09-04 | Iowa State | UNI | REG (Non-Conf) | W 16-10 | ||
| 2 | 10 | 2 | 2021-09-11 | Iowa State | Iowa | REG (Non-Conf) | L 17-27 | ||
| 3 | 11 | 3 | 2021-09-18 | Iowa State | @ | Nevada-Las Vegas | REG (Non-Conf) | W 48-3 | |
| 4 | 12 | 4 | 2021-09-25 | Iowa State | @ | Baylor | REG (Conf) | L 29-31 | |
| 5 | 13 | 5 | 2021-10-02 | Iowa State | Kansas | REG (Conf) | W 59-7 | ||
| 6 | 14 | 6 | 2021-10-16 | Iowa State | @ | Kansas State | REG (Conf) | W 33-20 | |
| 7 | 15 | 7 | 2021-10-23 | Iowa State | Oklahoma State | REG (Conf) | W 24-21 | ||
| 8 | 16 | 8 | 2021-10-30 | Iowa State | @ | West Virginia | REG (Conf) | L 31-38 | |
| 9 | 17 | 9 | 2021-11-06 | Iowa State | Texas | REG (Conf) | W 30-7 | ||
| 10 | 18 | 10 | 2021-11-13 | Iowa State | @ | Texas Tech | REG (Conf) | L 38-41 | |
| 11 | 19 | 11 | 2021-11-20 | Iowa State | @ | Oklahoma | REG (Conf) | L 21-28 | |
| 12 | 20 | 12 | 2021-11-26 | Iowa State | Texas Christian | REG (Conf) | W 48-14 | ||
| 13 | 21 | 13 | 2021-12-29 | Iowa State | N | Clemson | Bowl | L 13-20 | Cheez-It Bowl |
| 7-6 |
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