| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 22 | 1 | 2021-09-04 | Missouri | Central Michigan | REG (Non-Conf) | W 34-24 | |
| 2 | 23 | 2 | 2021-09-11 | Missouri | @ | Kentucky | REG (Conf) | L 28-35 |
| 3 | 24 | 3 | 2021-09-18 | Missouri | Southeast Mo. St. | REG (Non-Conf) | W 59-28 | |
| 4 | 25 | 4 | 2021-09-25 | Missouri | @ | Boston College | REG (Non-Conf) | L 34-41 |
| 5 | 26 | 5 | 2021-10-02 | Missouri | Tennessee | REG (Conf) | L 24-62 | |
| 6 | 27 | 6 | 2021-10-09 | Missouri | North Texas | REG (Non-Conf) | W 48-35 | |
| 7 | 28 | 7 | 2021-10-16 | Missouri | Texas A&M | REG (Conf) | L 14-35 | |
| 8 | 29 | 8 | 2021-10-30 | Missouri | @ | Vanderbilt | REG (Conf) | W 37-28 |
| 9 | 30 | 9 | 2021-11-06 | Missouri | @ | Georgia | REG (Conf) | L 6-43 |
| 10 | 31 | 10 | 2021-11-13 | Missouri | South Carolina | REG (Conf) | W 31-28 | |
| 11 | 32 | 11 | 2021-11-20 | Missouri | Florida | REG (Conf) | W 24-23 | |
| 12 | 33 | 12 | 2021-11-26 | Missouri | @ | Arkansas | REG (Conf) | L 17-34 |
| 6-6 |
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