| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 3 | 1 | 2022-09-03 | Rice | @ | USC | REG (Non-Conf) | L 14-66 | |
| 2 | 4 | 2 | 2022-09-10 | Rice | McNeese St. | REG (Non-Conf) | W 52-10 | ||
| 3 | 5 | 4 | 2022-09-24 | Rice | @ | Houston | REG (Non-Conf) | L 27-34 | |
| 4 | 6 | 5 | 2022-10-01 | Rice | UAB | REG (Conf) | W 28-24 | ||
| 5 | 7 | 6 | 2022-10-15 | Rice | @ | Florida Atlantic | REG (Conf) | L 14-17 | |
| 6 | 8 | 7 | 2022-10-22 | Rice | @ | Louisiana Tech | REG (Conf) | W 42-41 (OT) | |
| 7 | 9 | 8 | 2022-10-29 | Rice | Charlotte | REG (Conf) | L 23-56 | ||
| 8 | 10 | 9 | 2022-11-03 | Rice | UTEP | REG (Conf) | W 37-30 | ||
| 9 | 11 | 10 | 2022-11-12 | Rice | @ | Western Kentucky | REG (Conf) | L 10-45 | |
| 10 | 12 | 11 | 2022-11-19 | Rice | UTSA | REG (Conf) | L 7-41 | ||
| 11 | 13 | 12 | 2022-11-26 | Rice | @ | North Texas | REG (Conf) | L 17-21 | |
| 12 | 14 | 13 | 2022-12-17 | Rice | N | Southern Mississippi | Bowl | L 24-38 | LendingTree Bowl |
| 4-8 |
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