| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 1 | 2021-09-04 | LSU | @ | UCLA | REG (Non-Conf) | L 27-38 |
| 2 | 2 | 2 | 2021-09-11 | LSU | McNeese St. | REG (Non-Conf) | W 34-7 | |
| 3 | 3 | 3 | 2021-09-18 | LSU | Central Michigan | REG (Non-Conf) | W 49-21 | |
| 4 | 4 | 4 | 2021-09-25 | LSU | @ | Mississippi State | REG (Conf) | W 28-25 |
| 5 | 5 | 5 | 2021-10-02 | LSU | Auburn | REG (Conf) | L 19-24 | |
| 6 | 6 | 6 | 2021-10-09 | LSU | @ | Kentucky | REG (Conf) | L 21-42 |
| 7 | 7 | 7 | 2021-10-16 | LSU | Florida | REG (Conf) | W 49-42 | |
| 8 | 8 | 8 | 2021-10-23 | LSU | @ | Ole Miss | REG (Conf) | L 17-31 |
| 9 | 9 | 9 | 2021-11-06 | LSU | @ | Alabama | REG (Conf) | L 14-20 |
| 10 | 10 | 10 | 2021-11-13 | LSU | Arkansas | REG (Conf) | L 13-16 | |
| 11 | 11 | 11 | 2021-11-20 | LSU | Louisiana-Monroe | REG (Non-Conf) | W 27-14 | |
| 12 | 12 | 12 | 2021-11-27 | LSU | Texas A&M | REG (Conf) | W 27-24 | |
| 6-6 |
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