| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 5 | 1 | 2021-09-03 | Michigan State | @ | Northwestern | REG (Conf) | W 38-21 | |
| 2 | 6 | 2 | 2021-09-11 | Michigan State | Youngstown St. | REG (Non-Conf) | W 42-14 | ||
| 3 | 7 | 3 | 2021-09-18 | Michigan State | @ | Miami (FL) | REG (Non-Conf) | W 38-17 | |
| 4 | 8 | 4 | 2021-09-25 | Michigan State | Nebraska | REG (Conf) | W 23-20 | ||
| 5 | 9 | 5 | 2021-10-02 | Michigan State | Western Kentucky | REG (Non-Conf) | W 48-31 | ||
| 6 | 10 | 6 | 2021-10-09 | Michigan State | @ | Rutgers | REG (Conf) | W 31-13 | |
| 7 | 11 | 8 | 2021-10-30 | Michigan State | Michigan | REG (Conf) | W 37-33 | ||
| 8 | 12 | 9 | 2021-11-06 | Michigan State | @ | Purdue | REG (Conf) | L 29-40 | |
| 9 | 13 | 10 | 2021-11-13 | Michigan State | Maryland | REG (Conf) | W 40-21 | ||
| 10 | 14 | 11 | 2021-11-20 | Michigan State | @ | Ohio State | REG (Conf) | L 7-56 | |
| 11 | 15 | 12 | 2021-11-27 | Michigan State | Penn State | REG (Conf) | W 30-27 | ||
| 12 | 16 | 13 | 2021-12-30 | Michigan State | N | Pitt | Bowl | W 31-21 | Peach Bowl |
| 10-2 |
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