| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 28 | 1 | 2021-09-04 | Iowa State | UNI | REG (Non-Conf) | W 16-10 | |
| 2 | 29 | 2 | 2021-09-11 | Iowa State | Iowa | REG (Non-Conf) | L 17-27 | |
| 3 | 30 | 3 | 2021-09-18 | Iowa State | @ | Nevada-Las Vegas | REG (Non-Conf) | W 48-3 |
| 4 | 31 | 4 | 2021-09-25 | Iowa State | @ | Baylor | REG (Conf) | L 29-31 |
| 5 | 32 | 5 | 2021-10-02 | Iowa State | Kansas | REG (Conf) | W 59-7 | |
| 6 | 33 | 6 | 2021-10-16 | Iowa State | @ | Kansas State | REG (Conf) | W 33-20 |
| 7 | 34 | 7 | 2021-10-23 | Iowa State | Oklahoma State | REG (Conf) | W 24-21 | |
| 8 | 35 | 8 | 2021-10-30 | Iowa State | @ | West Virginia | REG (Conf) | L 31-38 |
| 9 | 36 | 9 | 2021-11-06 | Iowa State | Texas | REG (Conf) | W 30-7 | |
| 10 | 37 | 10 | 2021-11-13 | Iowa State | @ | Texas Tech | REG (Conf) | L 38-41 |
| 11 | 38 | 11 | 2021-11-20 | Iowa State | @ | Oklahoma | REG (Conf) | L 21-28 |
| 12 | 39 | 12 | 2021-11-26 | Iowa State | Texas Christian | REG (Conf) | W 48-14 | |
| 7-5 |
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