| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 1 | 2020-09-12 | Louisville | Western Kentucky | REG (Non-Conf) | W 35-21 | |
| 2 | 2 | 2 | 2020-09-19 | Louisville | Miami (FL) | REG (Conf) | L 34-47 | |
| 3 | 3 | 4 | 2020-10-09 | Louisville | @ | Georgia Tech | REG (Conf) | L 27-46 |
| 4 | 4 | 5 | 2020-10-17 | Louisville | @ | Notre Dame | REG (Conf) | L 7-12 |
| 5 | 5 | 6 | 2020-10-24 | Louisville | Florida State | REG (Conf) | W 48-16 | |
| 6 | 6 | 7 | 2020-10-31 | Louisville | Virginia Tech | REG (Conf) | L 35-42 | |
| 7 | 7 | 8 | 2020-11-14 | Louisville | @ | Virginia | REG (Conf) | L 17-31 |
| 8 | 8 | 9 | 2020-11-20 | Louisville | Syracuse | REG (Conf) | W 30-0 | |
| 9 | 9 | 10 | 2020-11-28 | Louisville | @ | Boston College | REG (Conf) | L 27-34 |
| 10 | 10 | 11 | 2020-12-12 | Louisville | Wake Forest | REG (Conf) | W 45-21 | |
| 4-6 |
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