| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 17 | 4 | 2021-09-25 | Michigan State | Nebraska | REG (Conf) | W 23-20 | |
| 2 | 18 | 5 | 2021-10-02 | Michigan State | Western Kentucky | REG (Non-Conf) | W 48-31 | |
| 3 | 19 | 6 | 2021-10-09 | Michigan State | @ | Rutgers | REG (Conf) | W 31-13 |
| 4 | 20 | 9 | 2021-11-06 | Michigan State | @ | Purdue | REG (Conf) | L 29-40 |
| 5 | 21 | 10 | 2021-11-13 | Michigan State | Maryland | REG (Conf) | W 40-21 | |
| 6 | 22 | 11 | 2021-11-20 | Michigan State | @ | Ohio State | REG (Conf) | L 7-56 |
| 4-2 |
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