| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 11 | 1 | 2021-09-04 | Cincinnati | Miami (OH) | REG (Non-Conf) | W 49-14 | ||
| 2 | 12 | 2 | 2021-09-11 | Cincinnati | Murray St. | REG (Non-Conf) | W 42-7 | ||
| 3 | 13 | 3 | 2021-09-18 | Cincinnati | @ | Indiana | REG (Non-Conf) | W 38-24 | |
| 4 | 14 | 4 | 2021-10-02 | Cincinnati | @ | Notre Dame | REG (Non-Conf) | W 24-13 | |
| 5 | 15 | 5 | 2021-10-08 | Cincinnati | Temple | REG (Conf) | W 52-3 | ||
| 6 | 16 | 6 | 2021-10-16 | Cincinnati | UCF | REG (Conf) | W 56-21 | ||
| 7 | 17 | 7 | 2021-10-23 | Cincinnati | @ | Navy | REG (Conf) | W 27-20 | |
| 8 | 18 | 8 | 2021-10-30 | Cincinnati | @ | Tulane | REG (Conf) | W 31-12 | |
| 9 | 19 | 9 | 2021-11-06 | Cincinnati | Tulsa | REG (Conf) | W 28-20 | ||
| 10 | 20 | 10 | 2021-11-12 | Cincinnati | @ | South Florida | REG (Conf) | W 45-28 | |
| 11 | 21 | 11 | 2021-11-20 | Cincinnati | SMU | REG (Conf) | W 48-14 | ||
| 12 | 22 | 12 | 2021-11-26 | Cincinnati | @ | East Carolina | REG (Conf) | W 35-13 | |
| 13 | 23 | 13 | 2021-12-04 | Cincinnati | Houston | Conf Championship | W 35-20 | ||
| 14 | 24 | 14 | 2021-12-31 | Cincinnati | N | Alabama | CFB Semifinal | L 6-27 | Cotton Bowl |
| 13-1 |
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