| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 7 | 2 | 2022-09-10 | Buffalo | Holy Cross | REG (Non-Conf) | L 31-37 | ||
| 2 | 8 | 4 | 2022-09-24 | Buffalo | @ | Eastern Michigan | REG (Conf) | W 50-31 | |
| 3 | 9 | 6 | 2022-10-08 | Buffalo | @ | Bowling Green | REG (Conf) | W 38-7 | |
| 4 | 10 | 7 | 2022-10-15 | Buffalo | @ | Massachusetts | REG (Non-Conf) | W 34-7 | |
| 5 | 11 | 8 | 2022-10-22 | Buffalo | Toledo | REG (Conf) | W 34-27 | ||
| 6 | 12 | 9 | 2022-11-01 | Buffalo | @ | Ohio | REG (Conf) | L 24-45 | |
| 7 | 13 | 10 | 2022-11-09 | Buffalo | @ | Central Michigan | REG (Conf) | L 27-31 | |
| 8 | 14 | 11 | 2022-11-26 | Buffalo | Kent State | REG (Conf) | L 27-30 (OT) | ||
| 9 | 15 | 12 | 2022-12-02 | Buffalo | Akron | REG (Conf) | W 23-22 | ||
| 10 | 16 | 13 | 2022-12-27 | Buffalo | N | Georgia Southern | Bowl | W 23-21 | Camellia Bowl |
| 6-4 |
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