| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 25 | 1 | 2021-09-04 | Wyoming | Montana St. | REG (Non-Conf) | W 19-16 | ||
| 2 | 26 | 2 | 2021-09-11 | Wyoming | @ | Northern Illinois | REG (Non-Conf) | W 50-43 | |
| 3 | 27 | 3 | 2021-09-18 | Wyoming | Ball State | REG (Non-Conf) | W 45-12 | ||
| 4 | 28 | 4 | 2021-09-25 | Wyoming | @ | Connecticut | REG (Non-Conf) | W 24-22 | |
| 5 | 29 | 5 | 2021-10-09 | Wyoming | @ | Air Force | REG (Conf) | L 14-24 | |
| 6 | 30 | 6 | 2021-10-16 | Wyoming | Fresno State | REG (Conf) | L 0-17 | ||
| 7 | 31 | 8 | 2021-10-30 | Wyoming | @ | San Jose State | REG (Conf) | L 21-27 | |
| 8 | 32 | 9 | 2021-11-06 | Wyoming | Colorado State | REG (Conf) | W 31-17 | ||
| 9 | 33 | 12 | 2021-11-27 | Wyoming | Hawaii | REG (Conf) | L 14-38 | ||
| 10 | 34 | 13 | 2021-12-21 | Wyoming | N | Kent State | Bowl | W 52-38 | Famous Idaho Potato Bowl |
| 6-4 |
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